The precise elaboration and specification of neuronal circuits is at the basis of any properly functioning nervous system. For circuits to be established, neurons form remarkably accurate connections with their target cells during development. How are these connections established? Neurons send out cell protrusions called axons, which navigate in a complex environment to reach their exact target, a process known as axon guidance. Understanding the key molecules that induce the formation of such precise circuits is crucial, because any failure in this process, either during development or following injury or disease, impairs the proper function of the nervous system.
We investigate the cellular and molecular mechanisms that enable axons to grow and to accurately find their targets during development. We are particularly interested in understanding the role of non-coding RNAs in this process.
- Marie-Laure Baudet, PI
- Stephanie Strohbücker, Postdoctoral fellow
- Eloina Corradi, PhD student
- Linda Masante, PhD student
- Simone Bridi, Lab technician
- Charlotte Hardion, Pre-doc
- Irene Dalla Costa, MSc student
- Simona Lafirenze, MSc student
- Giorgia Susin, Undergraduate student
- Christine Holt, Department of Physiology, Development and Neuroscience, University of Cambridge, United-Kingdom.
- Cei Abreu-Goodger, National Laboratory of Genomics for Biodiversity (Langebio), CINVESTAV, México.
- Vladimir Benes, EMBL Heidelberg, Germany
- Giovanni Stefani, Center for Integrative Biology (CIBio), University of Trento, Italy
- Sheref Mansy, Center for Integrative Biology (CIBio), University of Trento, Italy
Bellon A, Iyer A, Bridi S, Lee FC, Ovando-Vázquez C, Corradi E, Longhi S, Roccuzzo M, Strohbuecker S, Naik S, Sarkies P, Miska E, Abreu-Goodger C, Holt CE, Baudet ML (2017). miR-182 regulates Slit2-mediated axon guidance by modulating the local translation of a specific mRNA. Cell Rep. 2017 18(5):1171-1186.
Messina A, Bridi S, Bozza A, Bozzi Y, Baudet ML, Casarosa S (2016). Noggin1 overexpression in retinal progenitors affects bipolar cell generation. Int J Dev Biol 60(4-6):151-7
Iyer A, Bellon A and Baudet ML (2014). microRNAs in axon guidance. Frontiers in Cellular Neuroscience 8:78
Baudet ML, Bellon A, Holt CE (2013). Role of microRNAs in Semaphorin function and neural circuit formation. Seminars in Cell and Developmental Biology 24(3):146-55
Leung LC, Urbančič V, Baudet ML, Dwivedy A, Bayley TG, Lee AC, Harris WA, Holt CE (2013) Coupling of NF-protocadherin signaling to axon guidance by cue-induced translation. Nature Neuroscience. 2013 16(2):166-73
Baudet ML, Zivraj K, Abreu-Goodger C, Muldal A, Armisen J, Blenkiron C, Goldstein LD, Miska E and Holt CE (2012) miR-124 acts through coREST to control onset of Sema3A sensitivity in navigating retinal growth cones. Nature Neuroscience 15, 29-38.
Wong G, Baudet ML, Norden C, Leung L and Harris W (2012) Slit1b-Robo3 signaling and N-cadherin regulate apical process retraction in developing retinal ganglion cells. Journal of Neuroscience 32, 223-8.
Han L, Wen Z, Lynn RC, Baudet ML, Holt C, Sasaki Y, Bassell G and Zheng J (2011) Regulation of chemotropic turning of nerve growth cones by microRNA 134. Molecular Brain 4, 40.