Skip to main content
  • People
  • Esse3
  • Online teaching
  • Libraries
Logo Unitn
MyUnitn
MyUnitn

  • Academic calendar
  • E learning
  • Job opportunities
  • Laboratories
  • Staff
DEPARTMENT
CELLULAR, COMPUTATIONAL AND INTEGRATIVE BIOLOGY - CIBIO
  • Department
    • Organization
    • Staff
    • Seminars
    • Job Opportunities
    • Quality
    • Rules and regulation
    • Press room
    • About us
    • How to reach us
  • Didactics
    • Degrees
    • La valigetta del biotecnologo
    • Piano Nazionale Lauree Scientifiche (PNLS)
    • Percorso formazione insegnanti
    • Armenise-Harvard Summer Fellowships
  • Research
    • Programs
    • Laboratories
    • Core Facilities
    • Recent publications
  • Services
    • Teaching services
    • Enrolment and career
    • Other services
  • Third Mission
    • Fundraising
  • International mobility
    • Going abroad
    • Coming to Trento
 
  • Condividi questa pagina
Facebook Google Plus LinkedIn Twitter Mail Whatsapp 
Home | Research | Laboratories | Neurobiology & Development | Dulbecco Telethon Laboratory of Stem Cells and Regenerative Medicine

Dulbecco Telethon Laboratory of Stem Cells and Regenerative Medicine

  • Programs
  • Laboratories
    • Cancer Biology & Genomics
      • Armenise-Harvard Cancer Biology & Genetics
      • Armenise-Harvard Laboratory of Brain Disorders and Cancer
      • Bioinformatics and Computational Genomics
      • Biotechnology and nanomedicine
      • Cell Biology and Molecular Genetics
      • Chromatin Biology & Epigenetics
      • Computational and Functional Oncology
      • Experimental Cancer Biology
      • Genomic Screening
      • Radiobiology
      • Metabolism of Cell Growth and Neuronal Survival
      • Molecular Cancer Genetics
      • Protein Crystallography and Structure-based Drug Design
      • RNA Regulatory Networks
      • Stem Cells and Cancer Genomics
      • Translational Genomics
      • Transcriptional Networks
    • Cell and Molecular Biology
      • Armenise-Harvard Laboratory of Cell Division
      • Biophysics and Translational Cardiology
      • Chromosome Segregation Biology
      • Computational Modeling
      • Dulbecco Telethon Prions and Amyloids
      • Molecular and Cellular Neurobiology
      • Molecular Virology
      • Molecular and Cellular Ophthalmology
      • RNA and Disease Data Science
      • RNA Biology and Biotechnology
      • Virus-Cell Interaction
    • Microbiology and Synthetic Biology
      • Armenise-Harvard Synthetic and Reconstructive Biology
      • Artificial Biology
      • Bacterial Genetics & Physiology
      • Computational Metagenomics
      • Microbial Genomics
      • Synthetic and Structural Vaccinology
    • Neurobiology & Development
      • Armenise-Harvard Axonal Neurobiology
      • Dulbecco Telethon Biology of Synapses
      • Dulbecco Telethon Stem Cells and Regenerative Medicine
      • Neural Development and Regeneration
      • NeuroEpigenetics
      • Neurogenomic Biomarkers
      • Stem Cell Biology
      • Transcriptional Neurobiology
      • Translational Neurogenetics
      • Synaptic Plasticity
  • Core Facilities
  • Recent publications

Overview

Skeletal muscle is the most abundant tissue in the vertebrate body. Several hundreds of muscles are present in the human body. They are playing an important role not only in the control of movements and posture, but they are also required for respiration, for the control of body temperature, and they exert an important metabolic function. Although muscles appear superficially alike at different anatomical locations, in reality there is considerably more diversity than initially believed. Heterogeneity is apparent during development at the molecular and cellular level. Multiple waves of muscle precursors with different features appear before birth and, by differentiating into syncytial fibers, contribute to muscular diversification.
Skeletal muscle Importantly, not all the myogenic progenitors terminally differentiate into fibers during development, but a fraction of them remain in the adult muscles as undifferentiated pool of stem cells. These stem cells are mediating muscle repair. Under normal conditions skeletal muscles present a very powerful regenerative response when challenged by injury. Nevertheless, the regenerative potential is progressively lost under specific pathophysiological conditions, such as aging or a variety neuromuscular diseases, in which fibrotic tissue progressively replaces muscle fibers leading to an impairment of muscle function.
By employing a combination of innovative in vitro and in vivo approaches, we are exploring the cellular and molecular events responsible for the defective regenerative ability and for the accumulation of fibrotic tissue in diseased muscle in order to set up the basis for effective and highly specific therapeutic approaches.
Using the skeletal muscle system, a tissue that is characterized by a particularly rich presence of stem cells, we are studying the role of key signaling cascades, such as TGFβ, Notch and Wnt pathways in the regulation of the behavior and commitment of stem cells. This research will ultimately contribute to our comprehension of the general molecular mechanisms controlling stem cell lineage decisions and will increase our understanding of the pathologies characterized by their altered functionality. See also Dulbecco Telethon Institute Biressi Lab at the web site: https://www.telethon.it/cosa-facciamo/ricerca/ricercatori/stefano-augusto-maria-biressi/

Research directions

  • Stem cell dysfunction in neuromuscular diseases and aging
  • Stem cell heterogeneity
  • Mechanisms of fibrosis
  • Cell and gene therapy of muscle and developmental pathologies
  • In vitro modeling of muscle diseases
  • Myogenic specification and differentiation
  • Generation of myogenic cell lines suitable for cultural meat production

Group members

  • Stefano Biressi, PI
  • Michela Libergoli, PhD student
  • Francesca Florio, PhD student
  • Giulia Fioravanti, PhD student

Collaborations

  • Luciano Conti, Dip. CIBio, University of Trento
  • Giovanni Piccoli, Dip. CIBio, University of Trento
  • Jessika Bertacchini, Universita’ di Modena
  • Yvan Torrente, Universita' degli Studi di Milano
  • Lorenzo Giordani, Sorbonne Université
  • Thomas Rando, Stanford University
  • Maria Pennuto, Universita’ di Padova
  • Mattia Pelizzola, Istituto Italiano di Tecnologia (iit), Milano

Selected publications

Magarò MS, Bertacchini J, Florio F, Zavatti M, Potì F, Cavani F, Amore E, De Santis I, Bevilacqua A, Reggiani Bonetti L, Torricelli P, Maurel DB, Biressi S., Palumbo C. “Identification of Sclerostin as a Putative New Myokine Involved in the Muscle-to-Bone Crosstalk”. Biomedicines. 2021: 9(1):E71.

Biressi S., Filareto A, Rando TA. "Stem cell therapy for muscular dystrophies". J Clin Invest. 2020;130(11):5652-5664.

Kheir E, Cusella G, Messina G, Cossu G, & Biressi S. Reporter-based Isolation of Developmental Myogenic Progenitors. Front Physiol. 2018; 5;9:352.

de Morrée A, van Velthoven C, Gan Q, Salvi JS, Klein JD, Akimenko I, Quarta M, Biressi S., and Rando TA. “Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence”. PNAS. 2017; 114(43), E8996-9005.

Biressi S., and Gopinath, SD. The quasi-parallel lives of satellite cells and atrophying muscle. Front. Aging Neurosci. 2015; 7, 140.

Biressi S., Miyabara EH, Gopinath SD, Carlig PMM, Rando TA. “A Wnt-TGFβ2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice”. Sci Transl Med. 2014; 267, 176.

George RM*, Biressi S.*, Beres B, Rogers R, Geiger L, Mulia A, Allen ER, Rawls A, Rando TA and Wilson-Rawls J. “Numb deficient satellite cells have a regeneration and proliferation defect”. *These authors equally contributed to this work. PNAS. 2013; 110(46), 18549-54.

Biressi S., Bjornson CRR, Carlig PMM, Nishijo K, Keller C, Rando TA. “Myf5 expression during fetal myogenesis defines the developmental progenitors of adult satellite cells”. Dev Biol. 2013; 379(2), 195-207.

Messina G*, Biressi S.*, Monteverde S, Magli A, Cassano M, Perani L, Roncaglia E, Tagliafico E, Starnes L, Cambpell CE, Grossi M, Goldhamer DJ, Gronostajski RM, Cossu G. “Nfix regulates fetal specific transcription in developing skeletal muscle”. *These authors equally contributed to this work. Cell. 2010; 140 (4), 554-66.

Biressi S., Rando TA. “Heterogeneity in the muscle satellite cell population”. Semin Cell Dev Biol. 2010; 21(8), 845-54.

For a complete list: http://www.ncbi.nlm.nih.gov/pubmed/?term=Biressi+S

Stefano Biressi, PI
via Sommarive n. 9, 38123 Povo (TN)
Ph. 
+39 0461 285290
Fax 
+39 0461 283937
stefano.biressi [at] unitn.it