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Latest publications of CIBIO affiliates (last updated on May 1st, 2018)

Rubin MA, Demichelis F (2018) The Genomics of Prostate Cancer: A Historic Perspective. Cold Spring Harb Perspect Med, doi:10.1101/cshperspect.a034942.
http://www.ncbi.nlm.nih.gov/pubmed/29712681

Cristofaro I, Spinello Z, Matera C, Fiore M, Conti L, De Amici M, Dallanoce C, Tata AM (2018) Activation of M2 muscarinic acetylcholine receptors by a hybrid agonist enhances cytotoxic effects in GB7 glioblastoma cancer stem cells. Neurochem. Int., doi:10.1016/j.neuint.2018.04.010.
http://www.ncbi.nlm.nih.gov/pubmed/29702145

Wray NR, Ripke S, …, DePaulo JR, Domenici E, Domschke K, Esko T, Grabe HJ, Hamilton SP, Hayward C, Heath AC, Hinds DA, Kendler KS, Kloiber S, Lewis G, Li QS, Lucae S, Madden PFA, Magnusson PK, Martin NG, McIntosh AM, Metspalu A, Mors O, Mortensen PB, Müller-Myhsok B, Nordentoft M, Nöthen MM, O'Donovan MC, Paciga SA, Pedersen NL, Penninx BWJH, Perlis RH, Porteous DJ, Potash JB, Preisig M, Rietschel M, Schaefer C, Schulze TG, Smoller JW, Stefansson K, Tiemeier H, Uher R, Völzke H, Weissman MM, Werge T, Winslow AR, Lewis CM, Levinson DF, Breen G, Børglum AD, Sullivan PFMajor Depressive Disorder Working Group of the Psychiatric Genomics Consortium,  (2018) Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat. Genet., doi:10.1038/s41588-018-0090-3.
http://www.ncbi.nlm.nih.gov/pubmed/29700475

Sidarovich V, De Mariano M, Aveic S, Pancher M, Adami V, Gatto P, Pizzini S, Pasini L, Croce M, Parodi F, Cimmino F, Avitabile M, Emionite L, Cilli M, Ferrini S, Pagano A, Capasso M, Quattrone A, Tonini GP, Longo L (2018) A high-content screening of anti-cancer compounds suggests the multiple tyrosine kinase inhibitor ponatinib for repurposing in neuroblastoma therapy. Mol. Cancer Ther., doi:10.1158/1535-7163.MCT-17-0841.
http://www.ncbi.nlm.nih.gov/pubmed/29695637

Fagnocchi L, Poli V, Zippo A (2018) Enhancer reprogramming in tumor progression: a new route towards cancer cell plasticity. Cell. Mol. Life Sci., doi:10.1007/s00018-018-2820-1.
http://www.ncbi.nlm.nih.gov/pubmed/29691590

Kheir E, Cusella G, Messina G, Cossu G, Biressi S (2018) Reporter-Based Isolation of Developmental Myogenic Progenitors. Front Physiol, 9:352, doi:10.3389/fphys.2018.00352.
http://www.ncbi.nlm.nih.gov/pubmed/29674978

Zasso J, Mastad A, Cutarelli A, Conti L (2018) Inducible alpha-synuclein expression affects human Neural Stem Cell behavior. Stem Cells Dev., doi:10.1089/scd.2018.0011.
http://www.ncbi.nlm.nih.gov/pubmed/29669468

Avogaro L, Querido E, Dalachi M, Jantsch MF, Chartrand P, Cusanelli E (2018) Live-cell imaging reveals the dynamics and function of single-telomere TERRA molecules in cancer cells. RNA Biol, doi:10.1080/15476286.2018.1456300.
http://www.ncbi.nlm.nih.gov/pubmed/29658398

Pinazza M, Ghisi M, Minuzzo S, Agnusdei V, Fossati G, Ciminale V, Pezzè L, Ciribilli Y, Pilotto G, Venturoli C, Amadori A, Indraccolo S (2018) Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells. Oncogene, doi:10.1038/s41388-018-0234-z.
http://www.ncbi.nlm.nih.gov/pubmed/29643474

Negro S, Stazi M, Marchioretto M, Tebaldi T, Rodella U, Duregotti E, Gerke V, Quattrone A, Montecucco C, Rigoni M, Viero G (2018) Hydrogen peroxide is a neuronal alarmin that triggers specific RNAs, local translation of Annexin A2 and cytoskeletal remodeling in Schwann cells. RNA, doi:10.1261/rna.064816.117.
http://www.ncbi.nlm.nih.gov/pubmed/29643068

Shaaban H, Westfall DA, Mohammad R, Danko D, Bezdan D, Afshinnekoo E, Segata N, Mason CE (2018) The Microbe Directory: An annotated, searchable inventory of microbes' characteristics. Gates Open Res, 2:3, doi:10.12688/gatesopenres.12772.1.
http://www.ncbi.nlm.nih.gov/pubmed/29630066

Sanna MD, Quattrone A, Galeotti N (2018) Antidepressant-like actions by silencing of neuronal ELAV-like RNA-binding proteins HuB and HuC in a model of depression in male mice. Neuropharmacology, 135:444-454, doi:10.1016/j.neuropharm.2018.04.001.
http://www.ncbi.nlm.nih.gov/pubmed/29626565

Pischedda F, Montani C, Obergasteiger J, Frapporti G, Corti C, Rosato Siri M, Volta M, Piccoli G (2018) Cryopreservation of Primary Mouse Neurons: The Benefit of Neurostore Cryoprotective Medium. Front Cell Neurosci, 12:81, doi:10.3389/fncel.2018.00081.
http://www.ncbi.nlm.nih.gov/pubmed/29623032

Francescatto M, Chierici M, Rezvan Dezfooli S, Zandonà A, Jurman G, Furlanello C (2018) Multi-omics integration for neuroblastoma clinical endpoint prediction. Biol. Direct, 13(1):5, doi:10.1186/s13062-018-0207-8.
http://www.ncbi.nlm.nih.gov/pubmed/29615097

Perez-Romero CA, Lalonde M, Chartrand P, Cusanelli E (2018) Induction and relocalization of telomeric repeat-containing RNAs during diauxic shift in budding yeast. Curr. Genet., doi:10.1007/s00294-018-0829-5.
http://www.ncbi.nlm.nih.gov/pubmed/29569051

Schwarz-Schilling M, Dupin A, Chizzolini F, Krishnan S, Mansy SS, Simmel FC (2018) Optimized Assembly of a Multifunctional RNA-Protein Nanostructure in a Cell-Free Gene Expression System. Nano Lett., 18(4):2650-2657, doi:10.1021/acs.nanolett.8b00526.
http://www.ncbi.nlm.nih.gov/pubmed/29564885

Segata N (2016) On the Road to Strain-Resolved Comparative Metagenomics. mSystems, 3(2), doi:10.1128/mSystems.00190-17.
http://www.ncbi.nlm.nih.gov/pubmed/29556534

Thongon N, Zucal C, D'Agostino VG, Tebaldi T, Ravera S, Zamporlini F, Piacente F, Moschoi R, Raffaelli N, Quattrone A, Nencioni A, Peyron JF, Provenzani A (2018) Cancer cell metabolic plasticity allows resistance to NAMPT inhibition but invariably induces dependence on LDHA. Cancer Metab, 6:1, doi:10.1186/s40170-018-0174-7.
http://www.ncbi.nlm.nih.gov/pubmed/29541451

Perez Carrion M, Pischedda F, Biosa A, Russo I, Straniero L, Civiero L, Guida M, Gloeckner CJ, Ticozzi N, Tiloca C, Mariani C, Pezzoli G, Duga S, Pichler I, Pan L, Landers JE, Greggio E, Hess MW, Goldwurm S, Piccoli G (2018) The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP+ Treatment by Altering LRRK2 Binding to DRP1. Front Mol Neurosci, 11:64, doi:10.3389/fnmol.2018.00064.
http://www.ncbi.nlm.nih.gov/pubmed/29541021

Poli V, Fagnocchi L, Fasciani A, Cherubini A, Mazzoleni S, Ferrillo S, Miluzio A, Gaudioso G, Vaira V, Turdo A, Giaggianesi M, Chinnici A, Lipari E, Bicciato S, Bosari S, Todaro M, Zippo A (2018) MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state. Nat Commun, 9(1):1024, doi:10.1038/s41467-018-03264-2.
http://www.ncbi.nlm.nih.gov/pubmed/29523784

Pinto F, Tett A, Armanini F, Asnicar F, Boscaini A, Pasolli E, Zolfo M, Donati C, Salmaso N, Segata N (2018) Correction for Pinto et al., "Draft Genome Sequences of Novel Pseudomonas, Flavobacterium, and Sediminibacterium Strains from a Freshwater Ecosystem". Genome Announc, 6(10), doi:10.1128/genomeA.00169-18.
http://www.ncbi.nlm.nih.gov/pubmed/29519845

Barreca ML, Iraci N, Biggi S, Cecchetti V, Biasini E (2018) Pharmacological Agents Targeting the Cellular Prion Protein. Pathogens, 7(1), doi:10.3390/pathogens7010027.
http://www.ncbi.nlm.nih.gov/pubmed/29518975

Leulmi N, Sighel D, Defant A, Khenaka K, Boulahrouf A, Mancini I (2018) Nigericin and grisorixin methyl ester from the Algerian soil-living Streptomyces youssoufiensis SF10 strain: a computational study on their epimeric structures and evaluation of glioblastoma stem cells growth inhibition. Nat. Prod. Res., doi:10.1080/14786419.2018.1446014.
http://www.ncbi.nlm.nih.gov/pubmed/29513090

Korpela K, Costea P, Coelho LP, Kandels-Lewis S, Willemsen G, Boomsma DI, Segata N, Bork P (2018) Selective maternal seeding and environment shape the human gut microbiome. Genome Res., 28(4):561-568, doi:10.1101/gr.233940.117.
http://www.ncbi.nlm.nih.gov/pubmed/29496731

Ianeselli A, Orioli S, Spagnolli G, Faccioli P, Cupellini L, Jurinovich S, Mennucci B (2018) Atomic Detail of Protein Folding Revealed by an Ab Initio Reappraisal of Circular Dichroism. J. Am. Chem. Soc., 140(10):3674-3682, doi:10.1021/jacs.7b12399.
http://www.ncbi.nlm.nih.gov/pubmed/29473417

Chia K, Mazzolini J, Mione M, Sieger D (2018) Tumor initiating cells induce Cxcr4-mediated infiltration of pro-tumoral macrophages into the brain. Elife, 7, doi:10.7554/eLife.31918.
http://www.ncbi.nlm.nih.gov/pubmed/29465400

Dimitrov B, Himmelreich N, Hipgrave Ederveen AL, Lüchtenborg C, Okun JG, Breuer M, Hutter AM, Carl M, Guglielmi L, Hellwig A, Thiemann KC, Jost M, Peters V, Staufner C, Hoffmann GF, Hackenberg A, Paramasivam N, Wiemann S, Eils R, Schlesner M, Strahl S, Brügger B, Wuhrer M, Christoph Korenke G, Thiel C (2018) Cutis laxa, exocrine pancreatic insufficiency and altered cellular metabolomics as additional symptoms in a new patient with ATP6AP1-CDG. Mol Genet Metab pii: S1096-7192(17)30764-3.
https://www.ncbi.nlm.nih.gov/pubmed/29396028

Choi JH, Jeong YM, Kim S, Lee B, Ariyasiri K, Kim HT, Jung SH, Hwang KS, Choi TI, Park CO, Huh WK, Carl M, Rosenfeld JA, Raskin S, Ma A, Gecz J, Kim HG, Kim JS, Shin HC, Park DS, Gerlai R, Jamieson BB, Kim JS, Iremonger KJ, Lee SH, Shin HS, Kim CH (2018) Targeted knockout of a chemokine-like gene increases anxiety and fear responses. Proc Natl Acad Sci U S A. 115(5):E1041-E1050.
https://www.ncbi.nlm.nih.gov/pubmed/29339520

Haschka M, Karbon G, Fava LL, Villunger A (2018) Perturbing mitosis for anti-cancer therapy: is cell death the only answer? EMBO Rep., 19(3), doi:10.15252/embr.201745440.
http://www.ncbi.nlm.nih.gov/pubmed/29459486

Kundel F, Tosatto L, Whiten DR, Wirthensohn DC, Horrocks MH, Klenerman D (2018) Shedding light on aberrant interactions - a review of modern tools for studying protein aggregates. FEBS J., doi:10.1111/febs.14409.
http://www.ncbi.nlm.nih.gov/pubmed/29453901

Pinto F, Tett A, Armanini F, Asnicar F, Boscaini A, Pasolli E, Zolfo M, Donati C, Salmaso N, Segata N (2018) Draft Genome Sequences of Novel  Genome Announc, 6(5), doi:10.1128/genomeA.00009-18.
http://www.ncbi.nlm.nih.gov/pubmed/29437085

Casini A, Olivieri M, Petris G, Montagna C, Reginato G, Maule G, Lorenzin F, Prandi D, Romanel A, Demichelis F, Inga A, Cereseto A (2018) A highly specific SpCas9 variant is identified by in vivo screening in yeast. Nat. Biotechnol., 36(3):265-271, doi:10.1038/nbt.4066.
http://www.ncbi.nlm.nih.gov/pubmed/29431739

Ilkhanizadeh S, Sabelström H, Miroshnikova YA, Frantz A, Zhu W, Idilli A, Lakins JN, Schmidt C, Quigley DA, Fenster T, Yuan E, Trzeciak JR, Saxena S, Lindberg OR, Mouw JK, Burdick JA, Magnitsky S, Berger MS, Phillips JJ, Arosio D, Sun D, Weaver VM, Weiss WA, Persson AI (2018) Antisecretory Factor-Mediated Inhibition of Cell Volume Dynamics Produces Antitumor Activity in Glioblastoma. Mol. Cancer Res., 16(5):777-790, doi:10.1158/1541-7786.MCR-17-0413.
http://www.ncbi.nlm.nih.gov/pubmed/29431617

Chiarot E, Spagnuolo A, Maccari S, Naimo E, Acquaviva A, Cecchi R, Galletti B, Fabbrini M, Mori E, Ruggiero P, Grandi G, Fontana MR, Bensi G, Margarit I (2018) Protective effect of Group B Streptococcus type-III polysaccharide conjugates against maternal colonization, ascending infection and neonatal transmission in rodent models. Sci Rep, 8(1):2593, doi:10.1038/s41598-018-20609-5.
http://www.ncbi.nlm.nih.gov/pubmed/29416049

T Islam AM, Adlard PA, Finkelstein DI, Lewis V, Biggi S, Biasini E, Collins SJ (2018) Acute Neurotoxicity Models of Prion Disease. ACS Chem Neurosci, 9(3):431-445, doi:10.1021/acschemneuro.7b00517.
http://www.ncbi.nlm.nih.gov/pubmed/29393619

Čejková J, Hanczyc MM, Štěpánek F (2018) Multi-Armed Droplets as Shape-Changing Protocells. Artif. Life, 24(1):71-79, doi:10.1162/ARTL_a_00255.
http://www.ncbi.nlm.nih.gov/pubmed/29369709

Manzano R, Sorarú G, Grunseich C, Fratta P, Zuccaro E, Pennuto M, Rinaldi C (2018) Beyond motor neurons: expanding the clinical spectrum in Kennedy's disease. J. Neurol. Neurosurg. Psychiatry, doi:10.1136/jnnp-2017-316961.
http://www.ncbi.nlm.nih.gov/pubmed/29353237

Pop-Bica C, Pintea S, Cojocneanu-Petric R, Del Sal G, Piazza S, Wu ZH, Alencar AJ, Lossos IS, Berindan-Neagoe I, Calin GA (2018) MiR-181 family-specific behavior in different cancers: a meta-analysis view. Cancer Metastasis Rev., 37(1):17-32, doi:10.1007/s10555-017-9714-9.
http://www.ncbi.nlm.nih.gov/pubmed/29327093

Benelli M, Romagnoli D, Demichelis F (2018) Tumor purity quantification by clonal DNA methylation signatures. Bioinformatics, doi:10.1093/bioinformatics/bty011.
http://www.ncbi.nlm.nih.gov/pubmed/29325057

Manzoni L, Zucal C, Maio DD, D'Agostino VG, Thongon N, Bonomo I, Lal P, Miceli M, Baj V, Brambilla M, Cerofolini L, Elezgarai S, Biasini E, Luchinat C, Novellino E, Fragai M, Marinelli L, Provenzani A, Seneci P (2018) Interfering with HuR-RNA Interaction: Design, Synthesis and Biological Characterization of Tanshinone Mimics as Novel, Effective HuR Inhibitors. J. Med. Chem., 61(4):1483-1498, doi:10.1021/acs.jmedchem.7b01176.
http://www.ncbi.nlm.nih.gov/pubmed/29313684

Lanterna LA, Galliani S, Zangari R, Conti L, Brembilla C, Gritti P, Colleoni ML, Bernucci C (2018) Thyroid Autoantibodies and the Clinical Presentation of Moyamoya Disease: A Prospective Study. J Stroke Cerebrovasc Dis, 27(5):1194-1199, doi:10.1016/j.jstrokecerebrovasdis.2017.11.037.
http://www.ncbi.nlm.nih.gov/pubmed/29305275

Basso M, Chen HH, Tripathy D, Conte M, Apperley KYP, De Simone A, Keillor JW, Ratan R, Nebbioso A, Sarno F, Altucci L, Milelli A (2018) Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death. ChemMedChem, 13(3):227-230, doi:10.1002/cmdc.201700601.
http://www.ncbi.nlm.nih.gov/pubmed/29286587

Schulte B, Selyutina A, Opp S, Herschhorn A, Sodroski JG, Pizzato M, Diaz-Griffero F (2018) Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5. Virology, 515:52-65, doi:10.1016/j.virol.2017.12.005.
http://www.ncbi.nlm.nih.gov/pubmed/29268082

Sen S, Bonfio C, Mansy SS, Cowan JA (2018) Investigation of glutathione-derived electrostatic and hydrogen-bonding interactions and their role in defining Grx5 [2Fe-2S] cluster optical spectra and transfer chemistry. J. Biol. Inorg. Chem., 23(2):241-252, doi:10.1007/s00775-017-1525-5.
http://www.ncbi.nlm.nih.gov/pubmed/29264659

McIver LJ, Abu-Ali G, Franzosa EA, Schwager R, Morgan XC, Waldron L, Segata N, Huttenhower C (2018) bioBakery: a meta'omic analysis environment. Bioinformatics, 34(7):1235-1237, doi:10.1093/bioinformatics/btx754.
http://www.ncbi.nlm.nih.gov/pubmed/29194469

Aveic S, Corallo D, Porcù E, Pantile M, Boso D, Zanon C, Viola G, Sidarovich V, Mariotto E, Quattrone A, Basso G, Tonini GP (2018) TP-0903 inhibits neuroblastoma cell growth and enhances the sensitivity to conventional chemotherapy. Eur. J. Pharmacol., 818:435-448, doi:10.1016/j.ejphar.2017.11.016.
http://www.ncbi.nlm.nih.gov/pubmed/29154838

Tang TD, Cecchi D, Fracasso G, Accardi D, Coutable-Pennarun A, Mansy SS, Perriman AW, Anderson JLR, Mann S (2018) Gene-Mediated Chemical Communication in Synthetic Protocell Communities. ACS Synth Biol, 7(2):339-346, doi:10.1021/acssynbio.7b00306.
http://www.ncbi.nlm.nih.gov/pubmed/29091420

Puglia M, Landi C, Gagliardi A, Breslin L, Armini A, Brunetti J, Pini A, Bianchi L, Bini L (2018) The proteome speciation of an immortalized cystic fibrosis cell line: New perspectives on the pathophysiology of the disease. J Proteomics, 170:28-42, doi:10.1016/j.jprot.2017.09.013.
http://www.ncbi.nlm.nih.gov/pubmed/28970102

Laulagnier K, Javalet C, Hemming FJ, Chivet M, Lachenal G, Blot B, Chatellard C, Sadoul R (2018) Amyloid precursor protein products concentrate in a subset of exosomes specifically endocytosed by neurons. Cell. Mol. Life Sci., 75(4):757-773, doi:10.1007/s00018-017-2664-0.
http://www.ncbi.nlm.nih.gov/pubmed/28956068

Cardano M, Diaferia GR, Conti L, Baronchelli S, Sessa A, Broccoli V, Barbieri A, De Blasio P, Biunno I (2018) mSEL-1L deficiency affects vasculogenesis and neural stem cell lineage commitment. J. Cell. Physiol., 233(4):3152-3163, doi:10.1002/jcp.26153.
http://www.ncbi.nlm.nih.gov/pubmed/28816361

Rhoads MK, Hauk P, Terrell J, Tsao CY, Oh H, Raghavan SR, Mansy SS, Payne GF, Bentley WE (2018) Incorporating LsrK AI-2 quorum quenching capability in a functionalized biopolymer capsule. Biotechnol. Bioeng., 115(2):278-289, doi:10.1002/bit.26397.
http://www.ncbi.nlm.nih.gov/pubmed/28782813

Kissling WD, Ahumada JA, Bowser A, Fernandez M, Fernández N, García EA, Guralnick RP, Isaac NJB, Kelling S, Los W, McRae L, Mihoub JB, Obst M, Santamaria M, Skidmore AK, Williams KJ, Agosti D, Amariles D, Arvanitidis C, Bastin L, De Leo F, Egloff W, Elith J, Hobern D, Martin D, Pereira HM, Pesole G, Peterseil J, Saarenmaa H, Schigel D, Schmeller DS, Segata N, Turak E, Uhlir PF, Wee B, Hardisty AR (2018) Building essential biodiversity variables (EBVs) of species distribution and abundance at a global scale. Biol Rev Camb Philos Soc, 93(1):600-625, doi:10.1111/brv.12359.
http://www.ncbi.nlm.nih.gov/pubmed/28766908

Pennuto M, Rinaldi C (2018) From gene to therapy in spinal and bulbar muscular atrophy: Are we there yet? Mol. Cell. Endocrinol., 465:113-121, doi:10.1016/j.mce.2017.07.005.
http://www.ncbi.nlm.nih.gov/pubmed/28688959

Bozzi Y, Provenzano G, Casarosa S (2018) Neurobiological bases of autism-epilepsy comorbidity: a focus on excitation/inhibition imbalance. Eur. J. Neurosci., 47(6):534-548, doi:10.1111/ejn.13595.
http://www.ncbi.nlm.nih.gov/pubmed/28452083