Latest publications of CIBIO affiliates (last updated on July 1st, 2019)
Gandellini P, Casiraghi N, Rancati T, Benelli M, Doldi V, Romanel A, Colecchia M, Marenghi C, Valdagni R, Demichelis F, Zaffaroni N (2019) Core Biopsies from Prostate Cancer Patients in Active Surveillance Protocols Harbor PTEN and MYC Alterations. Eur Urol Oncol, 2(3):277-285, doi:10.1016/j.euo.2018.08.010.
http://www.ncbi.nlm.nih.gov/pubmed/31200842
Thomas AM, Segata N (2019) Multiple levels of the unknown in microbiome research. BMC Biol., 17(1):48, doi:10.1186/s12915-019-0667-z.
http://www.ncbi.nlm.nih.gov/pubmed/31189463
Vollmer W, Massidda O, Tomasz A (2019) The Cell Wall of Microbiol Spectr, 7(3), doi:10.1128/microbiolspec.GPP3-0018-2018.
http://www.ncbi.nlm.nih.gov/pubmed/31172911
Mandrioli J, Crippa V, Cereda C, Bonetto V, Zucchi E, Gessani A, Ceroni M, Chio A, D'Amico R, Monsurrò MR, Riva N, Sabatelli M, Silani V, Simone IL, Sorarù G, Provenzani A, D'Agostino VG, Carra S, Poletti A (2019) Proteostasis and ALS: protocol for a phase II, randomised, double-blind, placebo-controlled, multicentre clinical trial for colchicine in ALS (Co-ALS). BMJ Open, 9(5):e028486, doi:10.1136/bmjopen-2018-028486.
http://www.ncbi.nlm.nih.gov/pubmed/31152038
Renson A, Jones HE, Beghini F, Segata N, Zolnik CP, Usyk M, Moody TU, Thorpe L, Burk R, Waldron L, Dowd JB (2019) Sociodemographic variation in the oral microbiome. Ann Epidemiol, doi:10.1016/j.annepidem.2019.03.006.
http://www.ncbi.nlm.nih.gov/pubmed/31151886
Marte A, Russo I, Rebosio C, Valente P, Belluzzi E, Pischedda F, Montani C, Lavarello C, Petretto A, Fedele E, Baldelli P, Benfenati F, Piccoli G, Greggio E, Onofri F (2019) LRRK2 phosphorylation on synapsin I regulates glutamate release at presynaptic sites. J. Neurochem., doi:10.1111/jnc.14778.
http://www.ncbi.nlm.nih.gov/pubmed/31148170
Giorgio E, Lorenzati M, Rivetti di Val Cervo P, Brussino A, Cernigoj M, Della Sala E, Bartoletti Stella A, Ferrero M, Caiazzo M, Capellari S, Cortelli P, Conti L, Cattaneo E, Buffo A, Brusco A (2019) Allele-specific silencing as treatment for gene duplication disorders: proof-of-principle in autosomal dominant leukodystrophy. Brain, doi:10.1093/brain/awz139.
http://www.ncbi.nlm.nih.gov/pubmed/31143934
Wuyts S, Segata N (2019) At the forefront of the sequencing revolution-notes from the RNGS19 conference. Genome Biol., 20(1):93, doi:10.1186/s13059-019-1714-3.
http://www.ncbi.nlm.nih.gov/pubmed/31142365
Portik DM, Bell RC, Blackburn DC, Bauer AM, Barratt CD, Branch WR, Burger M, Channing A, Colston TJ, Conradie W, Dehling JM, Drewes RC, Ernst R, Greenbaum E, Gvoždík V, Harvey J, Hillers A, Hirschfeld M, Jongsma GFM, Kielgast J, Kouete MT, Lawson LP, Leaché AD, Loader SP, Lötters S, Meijden AV, Menegon M, Müller S, Nagy ZT, Ofori-Boateng C, Ohler A, Papenfuss TJ, Rößler D, Sinsch U, Rödel MO, Veith M, Vindum J, Zassi-Boulou AG, McGuire JA (2019) Sexual Dichromatism Drives Diversification within a Major Radiation of African Amphibians. Syst. Biol., doi:10.1093/sysbio/syz023.
http://www.ncbi.nlm.nih.gov/pubmed/31140573
La Monica S, Minari R, Cretella D, Flammini L, Fumarola C, Bonelli M, Cavazzoni A, Digiacomo G, Galetti M, Madeddu D, Falco A, Lagrasta CA, Squadrilli A, Barocelli E, Romanel A, Quaini F, Petronini PG, Tiseo M, Alfieri R (2019) Third generation EGFR inhibitor osimertinib combined with pemetrexed or cisplatin exerts long-lasting anti-tumor effect in EGFR-mutated pre-clinical models of NSCLC. J. Exp. Clin. Cancer Res., 38(1):222, doi:10.1186/s13046-019-1240-x.
http://www.ncbi.nlm.nih.gov/pubmed/31138260
Meschini S, Pellegrini E, Maestri CA, Condello M, Bettotti P, Condello G, Scarpa M (2019) In vitro toxicity assessment of hydrogel patches obtained by cation-induced cross-linking of rod-like cellulose nanocrystals. J. Biomed. Mater. Res. Part B Appl. Biomater., doi:10.1002/jbm.b.34423.
http://www.ncbi.nlm.nih.gov/pubmed/31134760
Pivetti S, Fernandez-Perez D, D'Ambrosio A, Barbieri CM, Manganaro D, Rossi A, Barnabei L, Zanotti M, Scelfo A, Chiacchiera F, Pasini D (2019) Loss of PRC1 activity in different stem cell compartments activates a common transcriptional program with cell type-dependent outcomes. Sci Adv, 5(5):eaav1594, doi:10.1126/sciadv.aav1594.
http://www.ncbi.nlm.nih.gov/pubmed/31106267
Locallo A, Prandi D, Fedrizzi T, Demichelis F (2019) TPES: Tumor Purity Estimation from SNVs. Bioinformatics, doi:10.1093/bioinformatics/btz406.
http://www.ncbi.nlm.nih.gov/pubmed/31099386
Huckins LM, Dobbyn A, Ruderfer DM, Hoffman G, Wang W, Pardiñas AF, Rajagopal VM, Als TD, T Nguyen H, Girdhar K, Boocock J, Roussos P, Fromer M, Kramer R, Domenici E, Gamazon ER, Purcell S, CommonMind Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, iPSYCH-GEMS Schizophrenia Working Group, Demontis D, Børglum AD, Walters JTR, O'Donovan MC, Sullivan P, Owen MJ, Devlin B, Sieberts SK, Cox NJ, Im HK, Sklar P, Stahl EA (2019) Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nat. Genet., 51(6):1068, doi:10.1038/s41588-019-0435-6.
http://www.ncbi.nlm.nih.gov/pubmed/31086353
Beghini F, Renson A, Zolnik CP, Geistlinger L, Usyk M, Moody TU, Thorpe L, Dowd JB, Burk R, Segata N, Jones HE, Waldron L (2019) Tobacco exposure associated with oral microbiota oxygen utilization in the New York City Health and Nutrition Examination Study. Ann Epidemiol, 34:18-25.e3, doi:10.1016/j.annepidem.2019.03.005.
http://www.ncbi.nlm.nih.gov/pubmed/31076212
Abida W, Cyrta J, Heller G, Prandi D, Armenia J, Coleman I, Cieslik M, Benelli M, Robinson D, Van Allen EM, Sboner A, Fedrizzi T, Mosquera JM, Robinson BD, De Sarkar N, Kunju LP, Tomlins S, Wu YM, Nava Rodrigues D, Loda M, Gopalan A, Reuter VE, Pritchard CC, Mateo J, Bianchini D, Miranda S, Carreira S, Rescigno P, Filipenko J, Vinson J, Montgomery RB, Beltran H, Heath EI, Scher HI, Kantoff PW, Taplin ME, Schultz N, deBono JS, Demichelis F, Nelson PS, Rubin MA, Chinnaiyan AM, Sawyers CL (2019) Genomic correlates of clinical outcome in advanced prostate cancer. Proc. Natl. Acad. Sci. U.S.A., 116(23):11428-11436, doi:10.1073/pnas.1902651116.
http://www.ncbi.nlm.nih.gov/pubmed/31061129
Rigoli M, Spagnolli G, Faccioli P, Requena JR, Biasini E (2019) Ok Google, how could I design therapeutics against prion diseases? Curr Opin Pharmacol, 44:39-45, doi:10.1016/j.coph.2019.03.015.
http://www.ncbi.nlm.nih.gov/pubmed/31059982
Notarangelo M, Zucal C, Modelska A, Pesce I, Scarduelli G, Potrich C, Lunelli L, Pederzolli C, Pavan P, la Marca G, Pasini L, Ulivi P, Beltran H, Demichelis F, Provenzani A, Quattrone A, D'Agostino VG (2019) Ultrasensitive detection of cancer biomarkers by nickel-based isolation of polydisperse extracellular vesicles from blood. EBioMedicine, 43:114-126, doi:10.1016/j.ebiom.2019.04.039.
http://www.ncbi.nlm.nih.gov/pubmed/31047861
Rossi M, Bucci G, Rizzotto D, Bordo D, Marzi MJ, Puppo M, Flinois A, Spadaro D, Citi S, Emionite L, Cilli M, Nicassio F, Inga A, Briata P, Gherzi R (2019) LncRNA EPR controls epithelial proliferation by coordinating Cdkn1a transcription and mRNA decay response to TGF-β. Nat Commun, 10(1):1969, doi:10.1038/s41467-019-09754-1.
http://www.ncbi.nlm.nih.gov/pubmed/31036808
Delgado-Gonzalez A, Robles-Remacho A, Marin-Romero A, Detassis S, Lopez-Longarela B, Lopez-Delgado FJ, de Miguel-Perez D, Guardia-Monteagudo JJ, Fara MA, Tabraue-Chavez M, Pernagallo S, Sanchez-Martin RM, Diaz-Mochon JJ (2019) PCR-free and chemistry-based technology for miR-21 rapid detection directly from tumour cells. Talanta, 200:51-56, doi:10.1016/j.talanta.2019.03.039.
http://www.ncbi.nlm.nih.gov/pubmed/31036216
Precazzini F, Pancher M, Gatto P, Tushe A, Adami V, Anelli V, Mione MC (2019) Automated in vivo screen in zebrafish identifies Clotrimazole as targeting a metabolic vulnerability in a melanoma model. Dev. Biol., doi:10.1016/j.ydbio.2019.04.005.
http://www.ncbi.nlm.nih.gov/pubmed/30998907
Della Volpe S, Nasti R, Queirolo M, Unver MY, Jumde VK, Dömling A, Vasile F, Potenza D, Ambrosio FA, Costa G, Alcaro S, Zucal C, Provenzani A, Di Giacomo M, Rossi D, Hirsch AKH, Collina S (2019) Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies. ACS Med Chem Lett, 10(4):615-620, doi:10.1021/acsmedchemlett.8b00600.
http://www.ncbi.nlm.nih.gov/pubmed/30996806
Breuer M, Guglielmi L, Zielonka M, Hemberger V, Kölker S, Okun JG, Hoffmann GF, Carl M, Sauer SW, Opladen T (2019) QDPR homologues in Danio rerio regulate melanin synthesis, early gliogenesis, and glutamine homeostasis. PLoS ONE, 14(4):e0215162, doi:10.1371/journal.pone.0215162.
http://www.ncbi.nlm.nih.gov/pubmed/30995231
Detassis S, Grasso M, Tabraue-Chávez M, Marín-Romero A, López-Longarela B, Ilyine H, Ress C, Ceriani S, Erspan M, Maglione A, Díaz-Mochón JJ, Pernagallo S, Denti MA (2019) New Platform for the Direct Profiling of microRNAs in Biofluids. Anal. Chem., 91(9):5874-5880, doi:10.1021/acs.analchem.9b00213.
http://www.ncbi.nlm.nih.gov/pubmed/30994325
Zhang X, Piano I, Messina A, D'Antongiovanni V, Crò F, Provenzano G, Bozzi Y, Gargini C, Casarosa S (2019) Retinal defects in mice lacking the autism-associated gene Engrailed-2. Neuroscience, 408:177-190, doi:10.1016/j.neuroscience.2019.03.061.
http://www.ncbi.nlm.nih.gov/pubmed/30980901
Castro-Díez P, Vaz AS, Silva JS, van Loo M, Alonso Á, Aponte C, Bayón Á, Bellingham PJ, Chiuffo MC, DiManno N, Julian K, Kandert S, Porta N, Marchante H, Maule HG, Mayfield MM, Metcalfe D, Monteverdi MC, Núñez MA, Ostertag R, Parker IM, Peltzer DA, Potgieter LJ, Raymundo M, Rayome D, Reisman-Berman O, Richardson DM, Roos RE, Saldaña A, Shackleton RT, Torres A, Trudgen M, Urban J, Vicente JR, Vilà M, Ylioja T, Zenni RD, Godoy O (2019) Global effects of non-native tree species on multiple ecosystem services. Biol Rev Camb Philos Soc, doi:10.1111/brv.12511.
http://www.ncbi.nlm.nih.gov/pubmed/30974048
Infantino V, Tutucci E, Yeh Martin N, Zihlmann A, Garcia-Molinero V, Silvano G, Palancade B, Stutz F (2019) The mRNA export adaptor Yra1 contributes to DNA double-strand break repair through its C-box domain. PLoS ONE, 14(4):e0206336, doi:10.1371/journal.pone.0206336.
http://www.ncbi.nlm.nih.gov/pubmed/30951522
Biasini E (2019) A designer chaperone against prion diseases. Nat Biomed Eng, 3(3):167-168, doi:10.1038/s41551-019-0367-6.
http://www.ncbi.nlm.nih.gov/pubmed/30948815
Knezović Florijan M, Ozretić P, Bujak M, Pezzè L, Ciribilli Y, Kaštelan Ž, Slade N, Hudolin T (2019) The role of p53 isoforms' expression and p53 mutation status in renal cell cancer prognosis. Urol. Oncol., doi:10.1016/j.urolonc.2019.03.007.
http://www.ncbi.nlm.nih.gov/pubmed/30948335
Thomas AM, Manghi P, Asnicar F, Pasolli E, Armanini F, Zolfo M, Beghini F, Manara S, Karcher N, Pozzi C, Gandini S, Serrano D, Tarallo S, Francavilla A, Gallo G, Trompetto M, Ferrero G, Mizutani S, Shiroma H, Shiba S, Shibata T, Yachida S, Yamada T, Wirbel J, Schrotz-King P, Ulrich CM, Brenner H, Arumugam M, Bork P, Zeller G, Cordero F, Dias-Neto E, Setubal JC, Tett A, Pardini B, Rescigno M, Waldron L, Naccarati A, Segata N (2019) Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation. Nat. Med., 25(4):667-678, doi:10.1038/s41591-019-0405-7.
http://www.ncbi.nlm.nih.gov/pubmed/30936548
Wirbel J, Pyl PT, Kartal E, Zych K, Kashani A, Milanese A, Fleck JS, Voigt AY, Palleja A, Ponnudurai R, Sunagawa S, Coelho LP, Schrotz-King P, Vogtmann E, Habermann N, Niméus E, Thomas AM, Manghi P, Gandini S, Serrano D, Mizutani S, Shiroma H, Shiba S, Shibata T, Yachida S, Yamada T, Waldron L, Naccarati A, Segata N, Sinha R, Ulrich CM, Brenner H, Arumugam M, Bork P, Zeller G (2019) Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer. Nat. Med., 25(4):679-689, doi:10.1038/s41591-019-0406-6.
http://www.ncbi.nlm.nih.gov/pubmed/30936547
Bizzego A, Bussola N, Chierici M, Maggio V, Francescatto M, Cima L, Cristoforetti M, Jurman G, Furlanello C (2019) Evaluating reproducibility of AI algorithms in digital pathology with DAPPER. PLoS Comput. Biol., 15(3):e1006269, doi:10.1371/journal.pcbi.1006269.
http://www.ncbi.nlm.nih.gov/pubmed/30917113
Huckins LM, Dobbyn A, Ruderfer DM, Hoffman G, Wang W, Pardiñas AF, Rajagopal VM, Als TD, T Nguyen H, Girdhar K, Boocock J, Roussos P, Fromer M, Kramer R, Domenici E, Gamazon ER, Purcell S, CommonMind Consortium, Schizophrenia Working Group of the Psychiatric Genomics Consortium, iPSYCH-GEMS Schizophrenia Working Group, Demontis D, Børglum AD, Walters JTR, O'Donovan MC, Sullivan P, Owen MJ, Devlin B, Sieberts SK, Cox NJ, Im HK, Sklar P, Stahl EA (2019) Gene expression imputation across multiple brain regions provides insights into schizophrenia risk. Nat. Genet., 51(4):659-674, doi:10.1038/s41588-019-0364-4.
http://www.ncbi.nlm.nih.gov/pubmed/30911161
Dolce D, Neri S, Grisotto L, Campana S, Ravenni N, Miselli F, Camera E, Zavataro L, Braggion C, Fiscarelli EV, Lucidi V, Cariani L, Girelli D, Faelli N, Colombo C, Lucanto C, Lombardo M, Magazzù G, Tosco A, Raia V, Manara S, Pasolli E, Armanini F, Segata N, Biggeri A, Taccetti G (2019) Methicillin-resistant Staphylococcus aureus eradication in cystic fibrosis patients: A randomized multicenter study. PLoS ONE, 14(3):e0213497, doi:10.1371/journal.pone.0213497.
http://www.ncbi.nlm.nih.gov/pubmed/30901344
Murthy V, Tebaldi T, Yoshida T, Erdin S, Calzonetti T, Vijayvargia R, Tripathi T, Kerschbamer E, Seong IS, Quattrone A, Talkowski ME, Gusella JF, Georgopoulos K, MacDonald ME, Biagioli M (2019) Hypomorphic mutation of the mouse Huntington's disease gene orthologue. PLoS Genet., 15(3):e1007765, doi:10.1371/journal.pgen.1007765.
http://www.ncbi.nlm.nih.gov/pubmed/30897080
Bettin N, Oss Pegorar C, Cusanelli E (2019) The Emerging Roles of TERRA in Telomere Maintenance and Genome Stability. Cells, 8(3), doi:10.3390/cells8030246.
http://www.ncbi.nlm.nih.gov/pubmed/30875900
Battistutta R, Lolli G (2019) Inhibitory Properties of ATP-Competitive Coumestrol and Boldine Are Correlated to Different Modulations of CK2 Flexibility. J. Nat. Prod., 82(4):1014-1018, doi:10.1021/acs.jnatprod.8b00889.
http://www.ncbi.nlm.nih.gov/pubmed/30840451
De Filippis F, Pasolli E, Tett A, Tarallo S, Naccarati A, De Angelis M, Neviani E, Cocolin L, Gobbetti M, Segata N, Ercolini D (2019) Distinct Genetic and Functional Traits of Human Intestinal Prevotella copri Strains Are Associated with Different Habitual Diets. Cell Host Microbe, 25(3):444-453.e3, doi:10.1016/j.chom.2019.01.004.
http://www.ncbi.nlm.nih.gov/pubmed/30799264
Wodak SJ, Paci E, Dokholyan NV, Berezovsky IN, Horovitz A, Li J, Hilser VJ, Bahar I, Karanicolas J, Stock G, Hamm P, Stote RH, Eberhardt J, Chebaro Y, Dejaegere A, Cecchini M, Changeux JP, Bolhuis PG, Vreede J, Faccioli P, Orioli S, Ravasio R, Yan L, Brito C, Wyart M, Gkeka P, Rivalta I, Palermo G, McCammon JA, Panecka-Hofman J, Wade RC, Di Pizio A, Niv MY, Nussinov R, Tsai CJ, Jang H, Padhorny D, Kozakov D, McLeish T (2019) Allostery in Its Many Disguises: From Theory to Applications. Structure, 27(4):566-578, doi:10.1016/j.str.2019.01.003.
http://www.ncbi.nlm.nih.gov/pubmed/30744993
Waldron L, Schiffer L, Azhar R, Ramos M, Geistlinger L, Segata N (2019) Waldron et al. Reply to "Commentary on the HMP16SData Bioconductor Package". Am. J. Epidemiol., 188(6):1031-1032, doi:10.1093/aje/kwz008.
http://www.ncbi.nlm.nih.gov/pubmed/30689687
Zielonka M, Probst J, Carl M, Hoffmann GF, Kölker S, Okun JG (2019) Bioenergetic dysfunction in a zebrafish model of acute hyperammonemic decompensation. Exp. Neurol., 314:91-99, doi:10.1016/j.expneurol.2019.01.008.
http://www.ncbi.nlm.nih.gov/pubmed/30653968
Zellweger F, De Frenne P, Lenoir J, Rocchini D, Coomes D (2019) Advances in Microclimate Ecology Arising from Remote Sensing. Trends Ecol. Evol. (Amst.), 34(4):327-341, doi:10.1016/j.tree.2018.12.012.
http://www.ncbi.nlm.nih.gov/pubmed/30651180
Schiffer L, Azhar R, Shepherd L, Ramos M, Geistlinger L, Huttenhower C, Dowd JB, Segata N, Waldron L (2019) HMP16SData: Efficient Access to the Human Microbiome Project Through Bioconductor. Am. J. Epidemiol., 188(6):1023-1026, doi:10.1093/aje/kwz006.
http://www.ncbi.nlm.nih.gov/pubmed/30649166
D'Agostino VG, Sighel D, Zucal C, Bonomo I, Micaelli M, Lolli G, Provenzani A, Quattrone A, Adami V (2019) Screening Approaches for Targeting Ribonucleoprotein Complexes: A New Dimension for Drug Discovery. SLAS Discov, 24(3):314-331, doi:10.1177/2472555218818065.
http://www.ncbi.nlm.nih.gov/pubmed/30616427
Pasternak G, Yang Y, Santos BB, Brunello F, Hanczyc MM, Motta A (2019) Regenerated silk fibroin membranes as separators for transparent microbial fuel cells. Bioelectrochemistry, 126:146-155, doi:10.1016/j.bioelechem.2018.12.004.
http://www.ncbi.nlm.nih.gov/pubmed/30597451
Zizioli D, Mione M, Varinelli M, Malagola M, Bernardi S, Alghisi E, Borsani G, Finazzi D, Monti E, Presta M, Russo D (2019) Zebrafish disease models in hematology: Highlights on biological and translational impact. Biochim Biophys Acta Mol Basis Dis, 1865(3):620-633, doi:10.1016/j.bbadis.2018.12.015.
http://www.ncbi.nlm.nih.gov/pubmed/30593895
Berto G, Ferreira-Cerca S, De Wulf P (2019) The Rio1 protein kinases/ATPases: conserved regulators of growth, division, and genomic stability. Curr. Genet., 65(2):457-466, doi:10.1007/s00294-018-0912-y.
http://www.ncbi.nlm.nih.gov/pubmed/30515528
Toparlak OD, Mansy SS (2019) Progress in synthesizing protocells. Exp. Biol. Med. (Maywood), 244(4):304-313, doi:10.1177/1535370218816657.
http://www.ncbi.nlm.nih.gov/pubmed/30509137
Ghensi P, Tonetto G, Soldini C, Bettio E, Mortellaro C, Soldini C (2019) Dental Implants With a Platform-Switched Morse Taper Connection and an Osteo Growth Induction Surface. J Craniofac Surg, 30(4):1049-1054, doi:10.1097/SCS.0000000000004795.
http://www.ncbi.nlm.nih.gov/pubmed/30394965
Ghensi P, Cucchi A, Bonaccorso A, Ferroni L, Gardin C, Mortellaro C, Zavan B (2019) In Vitro Effect of Bromelain on the Regenerative Properties of Mesenchymal Stem Cells. J Craniofac Surg, 30(4):1064-1067, doi:10.1097/SCS.0000000000004862.
http://www.ncbi.nlm.nih.gov/pubmed/30358745
Mezzavilla M, Notarangelo M, Concas MP, Catamo E, Gasparini P, Grillotti MG, Robino A (2019) Investigation of the link between PROP taste perception and vegetables consumption using FAOSTAT data. Int J Food Sci Nutr, 70(4):484-490, doi:10.1080/09637486.2018.1519527.
http://www.ncbi.nlm.nih.gov/pubmed/30304964
Rubin MA, Demichelis F (2019) The Genomics of Prostate Cancer: A Historic Perspective. Cold Spring Harb Perspect Med, 9(3), doi:10.1101/cshperspect.a034942.
http://www.ncbi.nlm.nih.gov/pubmed/29712681