Latest publications of CIBIO affiliates (last updated on December 1st, 2023)
Contenti J, Guo Y, Mazzu A, Irondelle M, Rouleau M, Lago C, Leva G, Tiberi L, Ben-Sahra I, Bost F, Mazure NM (2023) The mitochondrial NADH shuttle system is a targetable vulnerability for Group 3 medulloblastoma in a hypoxic microenvironment. Cell Death Dis, 14(11):784, doi:10.1038/s41419-023-06275-0.
http://www.ncbi.nlm.nih.gov/pubmed/38036520
Pergola G, Rampino A, Sportelli L, Borcuk CJ, Passiatore R, Di Carlo P, Marakhovskaia A, Fazio L, Amoroso N, Castro MN, Domenici E, Gennarelli M, Khlghatyan J, Kikidis GC, Lella A, Magri C, Monaco A, Papalino M, Parihar M, Popolizio T, Quarto T, Romano R, Torretta S, Valsecchi P, Zunuer H, Blasi G, Dukart J, Beaulieu JM, Bertolino A (2023) A miR-137-related biological pathway of risk for Schizophrenia is associated with human brain emotion processing. Biol Psychiatry Cogn Neurosci Neuroimaging, doi:10.1016/j.bpsc.2023.11.001.
http://www.ncbi.nlm.nih.gov/pubmed/38000716
Belkina AC, Roe CE, Tang VA, Back JB, Bispo C, Conway A, Chakraborty U, Daniels KT, de la Cruz G, Ferrer-Font L, Filby A, Gravano DM, Gregory MD, Hall C, Kukat C, Mozes A, Ordoñez-Rueda D, Orlowski-Oliver E, Pesce I, Porat Z, Poulton NJ, Reifel KM, Rieger AM, Sheridan RTC, Van Isterdael G, Walker RV (2023) Guidelines for establishing a cytometry laboratory. Cytometry A, doi:10.1002/cyto.a.24807.
http://www.ncbi.nlm.nih.gov/pubmed/37941128
Damizia M, Moretta GM, De Wulf P (2023) The RioK1 network determines p53 activity at multiple levels. Cell Death Discov, 9(1):410, doi:10.1038/s41420-023-01704-7.
http://www.ncbi.nlm.nih.gov/pubmed/37935656
Florio F, Vencato S, Papa FT, Libergoli M, Kheir E, Ghzaiel I, Rando TA, Torrente Y, Biressi S (2023) Combinatorial activation of the WNT-dependent fibrogenic program by distinct complement subunits in dystrophic muscle. EMBO Mol Med, doi:10.15252/emmm.202317405.
http://www.ncbi.nlm.nih.gov/pubmed/37927228
Rosso I, Jones-Weinert C, Rossiello F, Cabrini M, Brambillasca S, Munoz-Sagredo L, Lavagnino Z, Martini E, Tedone E, Garre' M, Aguado J, Parazzoli D, Mione M, Shay JW, Mercurio C, d'Adda di Fagagna F (2023) Alternative lengthening of telomeres (ALT) cells viability is dependent on C-rich telomeric RNAs. Nat Commun, 14(1):7086, doi:10.1038/s41467-023-42831-0.
http://www.ncbi.nlm.nih.gov/pubmed/37925537
Nicoletti G, Saler M, Tresoldi MM, Villani L, Tottoli EM, Jousson O, Faga A (2023) Effects of Comano Spring Water-derived Bacterial Lysates on Skin Regeneration: An In Vivo, 37(6):2498-2509, doi:10.21873/invivo.13357.
http://www.ncbi.nlm.nih.gov/pubmed/37905622
Tamburini S, Zhang Y, Gagliardi A, Di Lascio G, Caproni E, Benedet M, Tomasi M, Corbellari R, Zanella I, Croia L, Grandi G, Müller M, Grandi A (2023) Bacterial Outer Membrane Vesicles as a Platform for the Development of a Broadly Protective Human Papillomavirus Vaccine Based on the Minor Capsid Protein L2. Vaccines (Basel), 11(10), doi:10.3390/vaccines11101582.
http://www.ncbi.nlm.nih.gov/pubmed/37896984
Grandi A, Tomasi M, Ullah I, Bertelli C, Vanzo T, Accordini S, Gagliardi A, Zanella I, Benedet M, Corbellari R, Di Lascio G, Tamburini S, Caproni E, Croia L, Ravà M, Fumagalli V, Di Lucia P, Marotta D, Sala E, Iannacone M, Kumar P, Mothes W, Uchil PD, Cherepanov P, Bolognesi M, Pizzato M, Grandi G (2023) Immunogenicity and Pre-Clinical Efficacy of an OMV-Based SARS-CoV-2 Vaccine. Vaccines (Basel), 11(10), doi:10.3390/vaccines11101546.
http://www.ncbi.nlm.nih.gov/pubmed/37896949
Burigotto M, Vigorito V, Gliech C, Mattivi A, Ghetti S, Bisio A, Lolli G, Holland AJ, Fava LL (2023) PLK1 promotes the mitotic surveillance pathway by controlling cytosolic 53BP1 availability. EMBO Rep, doi:10.15252/embr.202357234.
http://www.ncbi.nlm.nih.gov/pubmed/37888778
Blanco-Míguez A, Gálvez EJC, Pasolli E, De Filippis F, Amend L, Huang KD, Manghi P, Lesker TR, Riedel T, Cova L, Punčochář M, Thomas AM, Valles-Colomer M, Schober I, Hitch TCA, Clavel T, Berry SE, Davies R, Wolf J, Spector TD, Overmann J, Tett A, Ercolini D, Segata N, Strowig T (2023) Extension of the Segatella copri complex to 13 species with distinct large extrachromosomal elements and associations with host conditions. Cell Host Microbe, 31(11):1804-1819.e9, doi:10.1016/j.chom.2023.09.013.
http://www.ncbi.nlm.nih.gov/pubmed/37883976
Lombardi C, Berti A, Cottini M, Roca E, Ventura L (2023) Using the 6-min walk test to assess the clinical response to mepolizumab and conventional therapy in severe eosinophilic asthma. ERJ Open Res, 9(5), doi:10.1183/23120541.00114-2023.
http://www.ncbi.nlm.nih.gov/pubmed/37868145
Maines E, Cardellini MC, Stringari G, Leonardi L, Piccoli G, Urru SAM, Maiorana A, Soffiati M, Franceschi R (2023) Drug-Induced Hypoglycemia in Neonates Born to Nondiabetic Women Treated with Medications during the Pregnancy or the Labor: A Systematic Review of the Literature. Am J Perinatol, doi:10.1055/s-0043-1776061.
http://www.ncbi.nlm.nih.gov/pubmed/37848046
Vojsovič M, Kratochvilová L, Valková N, Šislerová L, El Rashed Z, Menichini P, Inga A, Monti P, Brázda V (2023) Transactivation by partial function P53 family mutants is increased by the presence of G-quadruplexes at a promoter site. Biochimie, 216:14-23, doi:10.1016/j.biochi.2023.09.026.
http://www.ncbi.nlm.nih.gov/pubmed/37838351
Mencattelli G, Ndione MHD, Silverj A, Diagne MM, Curini V, Teodori L, Di Domenico M, Mbaye R, Leone A, Marcacci M, Gaye A, Ndiaye E, Diallo D, Ancora M, Secondini B, Di Lollo V, Mangone I, Bucciacchio A, Polci A, Marini G, Rosà R, Segata N, Fall G, Cammà C, Monaco F, Diallo M, Rota-Stabelli O, Faye O, Rizzoli A, Savini G (2023) Spatial and temporal dynamics of West Nile virus between Africa and Europe. Nat Commun, 14(1):6440, doi:10.1038/s41467-023-42185-7.
http://www.ncbi.nlm.nih.gov/pubmed/37833275
Ayyildiz D, Bergonzoni G, Monziani A, Tripathi T, Döring J, Kerschbamer E, Di Leva F, Pennati E, Donini L, Kovalenko M, Zasso J, Conti L, Wheeler VC, Dieterich C, Piazza S, Dassi E, Biagioli M (2023) CAG repeat expansion in the Huntington's disease gene shapes linear and circular RNAs biogenesis. PLoS Genet, 19(10):e1010988, doi:10.1371/journal.pgen.1010988.
http://www.ncbi.nlm.nih.gov/pubmed/37831730
Mirzoyan Z, Valenza A, Zola S, Bonfanti C, Arnaboldi L, Ferrari N, Pollard J, Lupi V, Cassinelli M, Frattaroli M, Sahin M, Pasini ME, Bellosta P (2023) A Drosophila model targets Eiger/TNFα to alleviate obesity-related insulin resistance and macrophage infiltration. Dis Model Mech, 16(11), doi:10.1242/dmm.050388.
http://www.ncbi.nlm.nih.gov/pubmed/37828911
Manara S, Beghini F, Masetti G, Armanini F, Geat D, Galligioni G, Segata N, Farina S, Cristofolini M (2023) Thermal Therapy Modulation of the Psoriasis-Associated Skin and Gut Microbiome. Dermatol Ther (Heidelb), 13(11):2769-2783, doi:10.1007/s13555-023-01036-5.
http://www.ncbi.nlm.nih.gov/pubmed/37768448
Pischedda F, Ghirelli A, Tripathi V, Piccoli G (2023) Negr1-Derived Peptides Trigger ALK Degradation and Halt Neuroblastoma Progression In Vitro and In Vivo. Pharmaceutics, 15(9), doi:10.3390/pharmaceutics15092307.
http://www.ncbi.nlm.nih.gov/pubmed/37765276
Martínez-Rojas VA, Pischedda F, Romero-Maldonado I, Khalaf B, Piccoli G, Macchi P, Musio C (2023) Nucleoporin Nup358 Downregulation Tunes the Neuronal Excitability in Mouse Cortical Neurons. Life (Basel), 13(9), doi:10.3390/life13091791.
http://www.ncbi.nlm.nih.gov/pubmed/37763196
Tambone E, Ceresa C, Marchetti A, Chiera S, Anesi A, Nollo G, Caola I, Bosetti M, Fracchia L, Ghensi P, Tessarolo F (2023) Rhamnolipid 89 Biosurfactant Is Effective against Int J Mol Sci, 24(18), doi:10.3390/ijms241814014.
http://www.ncbi.nlm.nih.gov/pubmed/37762317
Gao Y, Zimmer JT, Vasic R, Liu C, Gbyli R, Zheng SJ, Patel A, Liu W, Qi Z, Li Y, Nelakanti R, Song Y, Biancon G, Xiao AZ, Slavoff S, Kibbey RG, Flavell RA, Simon MD, Tebaldi T, Li HB, Halene S (2023) ALKBH5 modulates hematopoietic stem and progenitor cell energy metabolism through m Cell Rep, 42(10):113163, doi:10.1016/j.celrep.2023.113163.
http://www.ncbi.nlm.nih.gov/pubmed/37742191
Masè M, Viziano A, Strapazzon G, Alessandrini M, Micarelli A (2023) Auditory function in humans at high altitude. A scoping review. PLoS One, 18(9):e0291919, doi:10.1371/journal.pone.0291919.
http://www.ncbi.nlm.nih.gov/pubmed/37733697
Cutrupi F, Rossi M, Cadonna M, Poznanski E, Manara S, Postinghel M, Palumbi G, Bellisomi M, Nicosia E, Allaria G, Dondero L, Veneri C, Mancini P, Ferraro GB, Rosa G, Suffredini E, Foladori P, Grasselli E (2023) Evaluation of concentration procedures, sample pre-treatment, and storage condition for the detection of SARS-CoV-2 in wastewater. Environ Sci Pollut Res Int, 30(48):106660-106670, doi:10.1007/s11356-023-29696-y.
http://www.ncbi.nlm.nih.gov/pubmed/37733200
Mangiapane G, Pascut D, Dalla E, Antoniali G, Degrassi M, Crocè LS, De Sanctis V, Piazza S, Canarutto G, Tiribelli C, Tell G (2023) Clinical Significance of Apurinic/Apyrimidinic Endodeoxyribonuclease 1 and MicroRNA Axis in Hepatocellular Carcinoma. J Clin Transl Hepatol, 11(6):1291-1307, doi:10.14218/JCTH.2022.00179.
http://www.ncbi.nlm.nih.gov/pubmed/37719963
Manzato C, Larini L, Oss Pegorar C, Dello Stritto MR, Jurikova K, Jantsch V, Cusanelli E (2023) TERRA expression is regulated by the telomere-binding proteins POT-1 and POT-2 in Caenorhabditis elegans. Nucleic Acids Res, 51(19):10681-10699, doi:10.1093/nar/gkad742.
http://www.ncbi.nlm.nih.gov/pubmed/37713629
Bermingham KM, May A, Asnicar F, Capdevila J, Leeming ER, Franks PW, Valdes AM, Wolf J, Hadjigeorgiou G, Delahanty LM, Segata N, Spector TD, Berry SE (2023) Snack quality and snack timing are associated with cardiometabolic blood markers: the ZOE PREDICT study. Eur J Nutr, doi:10.1007/s00394-023-03241-6.
http://www.ncbi.nlm.nih.gov/pubmed/37709944
Ciancone-Chama AG, Bonaldo V, Biasini E, Bozzi Y, Balasco L (2023) Gene Expression Profiling in Trigeminal Ganglia from Cntnap2 Neuroscience, 531:75-85, doi:10.1016/j.neuroscience.2023.08.028.
http://www.ncbi.nlm.nih.gov/pubmed/37699442
Nogal A, Tettamanzi F, Dong Q, Louca P, Visconti A, Christiansen C, Breuninger T, Linseisen J, Grallert H, Wawro N, Asnicar F, Wong K, Baleanu AF, Michelotti GA, Segata N, Falchi M, Peters A, Franks PW, Bagnardi V, Spector TD, Bell JT, Gieger C, Valdes AM, Menni C (2023) A Fecal Metabolite Signature of Impaired Fasting Glucose: Results From Two Independent Population-Based Cohorts. Diabetes, 72(12):1870-1880, doi:10.2337/db23-0170.
http://www.ncbi.nlm.nih.gov/pubmed/37699401
Geistlinger L, Mirzayi C, Zohra F, Azhar R, Elsafoury S, Grieve C, Wokaty J, Gamboa-Tuz SD, Sengupta P, Hecht I, Ravikrishnan A, Gonçalves RS, Franzosa E, Raman K, Carey V, Dowd JB, Jones HE, Davis S, Segata N, Huttenhower C, Waldron L (2023) BugSigDB captures patterns of differential abundance across a broad range of host-associated microbial signatures. Nat Biotechnol, doi:10.1038/s41587-023-01872-y.
http://www.ncbi.nlm.nih.gov/pubmed/37697152
Donini L, Tanel R, Zuccarino R, Basso M (2023) Protein biomarkers for the diagnosis and prognosis of Amyotrophic Lateral Sclerosis. Neurosci Res, doi:10.1016/j.neures.2023.09.002.
http://www.ncbi.nlm.nih.gov/pubmed/37689321
Briguglio S, Cambria C, Albizzati E, Marcello E, Provenzano G, Frasca A, Antonucci F (2023) New Views of the DNA Repair Protein Ataxia-Telangiectasia Mutated in Central Neurons: Contribution in Synaptic Dysfunctions of Neurodevelopmental and Neurodegenerative Diseases. Cells, 12(17), doi:10.3390/cells12172181.
http://www.ncbi.nlm.nih.gov/pubmed/37681912
Chelini G, Trombetta EM, Fortunato-Asquini T, Ollari O, Pecchia T, Bozzi Y (2023) Automated Segmentation of the Mouse Body Language to Study Stimulus-Evoked Emotional Behaviors. eNeuro, 10(9), doi:10.1523/ENEURO.0514-22.2023.
http://www.ncbi.nlm.nih.gov/pubmed/37648448
Rivosecchi J, Cusanelli E (2023) TERRA beyond cancer: the biology of telomeric repeat-containing RNAs in somatic and germ cells. Front Aging, 4:1224225, doi:10.3389/fragi.2023.1224225.
http://www.ncbi.nlm.nih.gov/pubmed/37636218
Cottini M, Bondi B, Bagnasco D, Braido F, Passalacqua G, Licini A, Lombardi C, Berti A, Comberiati P, Landi M, Heffler E, Paoletti G (2023) Impulse oscillometry defined small airway dysfunction in asthmatic patients with normal spirometry: Prevalence, clinical associations, and impact on asthma control. Respir Med, 218:107391, doi:10.1016/j.rmed.2023.107391.
http://www.ncbi.nlm.nih.gov/pubmed/37595673
Cazzanelli G, Vedove AD, Parolin E, D'Agostino VG, Unzue A, Nevado C, Caflisch A, Lolli G (2023) Reevaluation of bromodomain ligands targeting BAZ2A. Protein Sci, 32(9):e4752, doi:10.1002/pro.4752.
http://www.ncbi.nlm.nih.gov/pubmed/37574751
Maines E, Urru SAM, Leonardi L, Fancellu E, Campomori A, Piccoli G, Maiorana A, Soffiati M, Franceschi R (2023) Drug-induced hyperinsulinemic hypoglycemia: An update on pathophysiology and treatment. Rev Endocr Metab Disord, doi:10.1007/s11154-023-09828-y.
http://www.ncbi.nlm.nih.gov/pubmed/37552352
Bussola N, Xu J, Wu L, Gorini L, Zhang Y, Furlanello C, Tong W (2023) A Weakly Supervised Deep Learning Framework for Whole Slide Classification to Facilitate Digital Pathology in Animal Study. Chem Res Toxicol, 36(8):1321-1331, doi:10.1021/acs.chemrestox.3c00058.
http://www.ncbi.nlm.nih.gov/pubmed/37540590
Garcia-Carpio I, Braun VZ, Weiler ES, Leone M, Niñerola S, Barco A, Fava LL, Villunger A (2023) Extra centrosomes induce PIDD1-mediated inflammation and immunosurveillance. EMBO J, 42(20):e113510, doi:10.15252/embj.2023113510.
http://www.ncbi.nlm.nih.gov/pubmed/37530438
Negri ML, D'Annunzio S, Vitali G, Zippo A (2023) May the force be with you: Nuclear condensates function beyond transcription control: Potential nongenetic functions of nuclear condensates in physiological and pathological conditions. Bioessays, 45(10):e2300075, doi:10.1002/bies.202300075.
http://www.ncbi.nlm.nih.gov/pubmed/37530178
Bermingham KM, Stensrud S, Asnicar F, Valdes AM, Franks PW, Wolf J, Hadjigeorgiou G, Davies R, Spector TD, Segata N, Berry SE, Hall WL (2023) Exploring the relationship between social jetlag with gut microbial composition, diet and cardiometabolic health, in the ZOE PREDICT 1 cohort. Eur J Nutr, 62(8):3135-3147, doi:10.1007/s00394-023-03204-x.
http://www.ncbi.nlm.nih.gov/pubmed/37528259
Zanin I, Ruggiero E, Nicoletto G, Lago S, Maurizio I, Gallina I, Richter SN (2023) Genome-wide mapping of i-motifs reveals their association with transcription regulation in live human cells. Nucleic Acids Res, 51(16):8309-8321, doi:10.1093/nar/gkad626.
http://www.ncbi.nlm.nih.gov/pubmed/37528048
Ricci L, Selma-Royo M, Golzato D, Nabinejad A, Servais C, Armanini F, Asnicar F, Pinto F, Tamburini S, Segata N (2023) Draft genome sequence of a representative strain of the Microbiol Resour Announc, 12(9):e0032923, doi:10.1128/MRA.00329-23.
http://www.ncbi.nlm.nih.gov/pubmed/37493508
Castellini ME, Spagnolli G, Poggi L, Biasini E, Casarosa S, Messina A (2023) Identification of the zebrafish homologues of IMPG2, a retinal proteoglycan. Cell Tissue Res, 394(1):93-105, doi:10.1007/s00441-023-03808-z.
http://www.ncbi.nlm.nih.gov/pubmed/37470839
Marchioretti C, Andreotti R, Zuccaro E, Lieberman AP, Basso M, Pennuto M (2023) Spinal and bulbar muscular atrophy: From molecular pathogenesis to pharmacological intervention targeting skeletal muscle. Curr Opin Pharmacol, 71:102394, doi:10.1016/j.coph.2023.102394.
http://www.ncbi.nlm.nih.gov/pubmed/37463556
Ichioka Y, Trullenque-Eriksson A, Ortiz-Vigón A, Guerrero A, Donati M, Bressan E, Ghensi P, Schaller D, Tomasi C, Karlsson K, Abrahamsson I, Dionigi C, Regidor E, Berglundh T, Derks J (2023) Factors influencing outcomes of surgical therapy of peri-implantitis: A secondary analysis of 1-year results from a randomized clinical study. J Clin Periodontol, 50(10):1282-1304, doi:10.1111/jcpe.13848.
http://www.ncbi.nlm.nih.gov/pubmed/37461197
Neri I, Ramazzotti G, Mongiorgi S, Rusciano I, Bugiani M, Conti L, Cousin M, Giorgio E, Padiath QS, Vaula G, Cortelli P, Manzoli L, Ratti S (2023) Understanding the Ultra-Rare Disease Autosomal Dominant Leukodystrophy: an Updated Review on Morpho-Functional Alterations Found in Experimental Models. Mol Neurobiol, 60(11):6362-6372, doi:10.1007/s12035-023-03461-1.
http://www.ncbi.nlm.nih.gov/pubmed/37450245
Thomas AM, Fidelle M, Routy B, Kroemer G, Wargo JA, Segata N, Zitvogel L (2023) Gut OncoMicrobiome Signatures (GOMS) as next-generation biomarkers for cancer immunotherapy. Nat Rev Clin Oncol, 20(9):583-603, doi:10.1038/s41571-023-00785-8.
http://www.ncbi.nlm.nih.gov/pubmed/37365438
Selma-Royo M, Segata N, Ricci L (2023) Human microbiome cultivation expands with AI. Nat Biotechnol, 41(10):1389-1391, doi:10.1038/s41587-023-01852-2.
http://www.ncbi.nlm.nih.gov/pubmed/37349525
Berti A, Cornec D, Dua AB (2023) Treatment Approaches to Granulomatosis with Polyangiitis and Microscopic Polyangiitis. Rheum Dis Clin North Am, 49(3):545-561, doi:10.1016/j.rdc.2023.03.004.
http://www.ncbi.nlm.nih.gov/pubmed/37331732
Handle F, Puhr M, Gruber M, Andolfi C, Schäfer G, Klocker H, Haybaeck J, De Wulf P, Culig Z (2023) The Oncogenic Protein Kinase/ATPase RIOK1 Is Up-Regulated via the c-myc/E2F Transcription Factor Axis in Prostate Cancer. Am J Pathol, 193(9):1284-1297, doi:10.1016/j.ajpath.2023.05.013.
http://www.ncbi.nlm.nih.gov/pubmed/37301535
Brentari I, Zadorozhna M, Denti MA, Giorgio E (2023) RNA therapeutics for neurological diseases. Br Med Bull, 147(1):50-61, doi:10.1093/bmb/ldad010.
http://www.ncbi.nlm.nih.gov/pubmed/37210633
Monti S, Milanesi A, Klersy C, Tomelleri A, Dagna L, Campochiaro C, Farina N, Muratore F, Galli E, Marvisi C, Bond M, Berti A, Bortolotti R, Padoan R, Schiavon F, Felicetti M, Nannini C, Cantini F, Giollo A, Rossini M, Conticini E, Frediani B, Conti F, Priori R, Sebastiani M, Cassone G, Quartuccio L, Treppo E, Bettio S, Hoxha A, Lovisotto M, Emmi G, Mattioli I, Leccese P, Caporali R, Argolini LM, Foti R, Visalli E, Colaci M, Salvarani C, Montecucco CItalian Society of Rheumatology Vasculitis Study Group, (2023) Age at diagnosis influences the clinical phenotype, treatment strategies and outcomes in patients with giant cell arteritis: results from the observational GCAGE study on a large cohort of 1004 patients. Ann Rheum Dis, 82(8):1098-1106, doi:10.1136/ard-2023-223895.
http://www.ncbi.nlm.nih.gov/pubmed/37188498
O'Toole PW, Ghosh TS, Goswami S, Manghi P, Segata N, Shanahan F (2023) Translating the Microbiome: What's the Target? Gastroenterology, 165(2):317-319, doi:10.1053/j.gastro.2023.04.008.
http://www.ncbi.nlm.nih.gov/pubmed/37094661
Blanco-Míguez A, Beghini F, Cumbo F, McIver LJ, Thompson KN, Zolfo M, Manghi P, Dubois L, Huang KD, Thomas AM, Nickols WA, Piccinno G, Piperni E, Punčochář M, Valles-Colomer M, Tett A, Giordano F, Davies R, Wolf J, Berry SE, Spector TD, Franzosa EA, Pasolli E, Asnicar F, Huttenhower C, Segata N (2023) Extending and improving metagenomic taxonomic profiling with uncharacterized species using MetaPhlAn 4. Nat Biotechnol, 41(11):1633-1644, doi:10.1038/s41587-023-01688-w.
http://www.ncbi.nlm.nih.gov/pubmed/36823356