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Latest publications of CIBIO affiliates (last updated on November 1st, 2018)

Roussigné M, Wei L, Tsingos E, Kuchling F, Alkobtawi M, Tsalavouta M, Wittbrodt J, Carl M, Blader P, Wilson SW. (2018) Left/right asymmetric collective migration of parapineal cells is mediated by focal FGF signaling activity in leading cells. Proc Natl Acad Sci U S A, 115(42):E9812-E9821, doi: 10.1073/pnas.1812016115.

Pollini D, Loffredo R, Cardano M, Conti L, Lattante S, Notarangelo A, Sabatelli M, Provenzani A (2018) Generation and characterization of a human iPSC line from an ALS patient carrying the Q66K-MATR3 mutation. Stem Cell Res, 33:146-150, doi:10.1016/j.scr.2018.10.011.

Ghensi P, Cucchi A, Bonaccorso A, Ferroni L, Gardin C, Mortellaro C, Zavan B (2018) In Vitro Effect of Bromelain on the Regenerative Properties of Mesenchymal Stem Cells. J Craniofac Surg, doi:10.1097/SCS.0000000000004862.

Clamer M, Tebaldi T, Lauria F, Bernabò P, Gómez-Biagi RF, Marchioretto M, Kandala DT, Minati L, Perenthaler E, Gubert D, Pasquardini L, Guella G, Groen EJN, Gillingwater TH, Quattrone A, Viero G (2018) Active Ribosome Profiling with RiboLace. Cell Rep, 25(4):1097-1108.e5, doi:10.1016/j.celrep.2018.09.084.

Gasperini L, Rossi A, Cornella N, Peroni D, Zuccotti P, Potrich V, Quattrone A, Macchi P (2018) The hnRNP raly regulates PRMT1 expression and interacts with the ALS-linked protein FUS: implication for reciprocal cellular localization. Mol. Biol. Cell, doi:10.1091/mbc.E18-02-0108.

O'Sullivan A, Salcedo J, Rubert J (2018) Correction to: Advanced analytical strategies for measuring free bioactive milk sugars: from composition and concentrations to human metabolic response. Anal Bioanal Chem, doi:10.1007/s00216-018-1389-8.

Mezzavilla M, Notarangelo M, Concas MP, Catamo E, Gasparini P, Grillotti MG, Robino A (2018) Investigation of the link between PROP taste perception and vegetables consumption using FAOSTAT data. Int J Food Sci Nutr, doi:10.1080/09637486.2018.1519527.

Pacchioni F, Esposito A, Giacobazzi E, Bettua C, Struffi P, Jousson O (2018) Air and waterborne microbiome of a pharmaceutical plant provide insights on spatiotemporal variations and community resilience after disturbance. BMC Microbiol., 18(1):124, doi:10.1186/s12866-018-1267-8.

Le Gall G, Guttula K, Kellingray L, Tett AJ, Ten Hoopen R, Kemsley KE, Savva GM, Ibrahim A, Narbad A (2018) Metabolite quantification of faecal extracts from colorectal cancer patients and healthy controls. Oncotarget, 9(70):33278-33289, doi:10.18632/oncotarget.26022.

Firrito C, Bertelli C, Vanzo T, Chande A, Pizzato M (2018) SERINC5 as a New Restriction Factor for Human Immunodeficiency Virus and Murine Leukemia Virus. Annu Rev Virol, 5(1):323-340, doi:10.1146/annurev-virology-092917-043308.

Nava Rodrigues D, Casiraghi N, Romanel A, Crespo M, Miranda S, Rescigno P, Figueiredo I, Riisnaes R, Carreira S, Sumanasuriya S, Gasperini P, Sharp A, Mateo J, Mackay A, McNair C, Schiewer MJ, Knudsen KE, Boysen G, Demichelis F, de Bono JS (2018) RB1 Heterogeneity in Advanced Metastatic Castration Resistant Prostate Cancer. Clin. Cancer Res., doi:10.1158/1078-0432.CCR-18-2068.

Poli V, Fagnocchi L, Fasciani A, Cherubini A, Mazzoleni S, Ferrillo S, Miluzio A, Gaudioso G, Vaira V, Turdo A, Gaggianesi M, Chinnici A, Lipari E, Bicciato S, Bosari S, Todaro M, Zippo A (2018) Author Correction: MYC-driven epigenetic reprogramming favors the onset of tumorigenesis by inducing a stem cell-like state. Nat Commun, 9(1):3921, doi:10.1038/s41467-018-06480-y.

Beltran H, Oromendia C, Danila DC, Montgomery B, Hoimes C, Szmulewitz RZ, Vaishampayan U, Armstrong AJ, Stein M, Pinski J, Mosquera JM, Sailer V, Bareja R, Romanel A, Gumpeni N, Sboner A, Dardenne E, Puca L, Prandi D, Rubin MA, Scher HI, Rickman DS, Demichelis F, Nanus DM, Ballman KV, Tagawa ST (2018) A phase II trial of the aurora kinase A inhibitor alisertib for patients with castration resistant and neuroendocrine prostate cancer: efficacy and biomarkers. Clin. Cancer Res., doi:10.1158/1078-0432.CCR-18-1912.

Vasile F, Della Volpe S, Ambrosio FA, Costa G, Unver MY, Zucal C, Rossi D, Martino E, Provenzani A, Hirsch AKH, Alcaro S, Potenza D, Collina S (2018) Exploration of ligand binding modes towards the identification of compounds targeting HuR: a combined STD-NMR and Molecular Modelling approach. Sci Rep, 8(1):13780, doi:10.1038/s41598-018-32084-z.

Ciacci N, D'Andrea MM, Marmo P, Demattè E, Amisano F, Di Pilato V, Fraziano M, Lupetti P, Rossolini GM, Thaller MC (2018) Characterization of vB_Kpn_F48, a Newly Discovered Lytic Bacteriophage for Klebsiella pneumoniae of Sequence Type 101. Viruses, 10(9), doi:10.3390/v10090482.

Zielonka M, Breuer M, Okun JG, Carl M, Hoffmann GF, Kölker S (2018) Pharmacologic rescue of hyperammonemia-induced toxicity in zebrafish by inhibition of ornithine aminotransferase. PLoS ONE, 13(9):e0203707, doi:10.1371/journal.pone.0203707.

Montagna C, Petris G, Casini A, Maule G, Franceschini GM, Zanella I, Conti L, Arnoldi F, Burrone OR, Zentilin L, Zacchigna S, Giacca M, Cereseto A (2018) VSV-G-Enveloped Vesicles for Traceless Delivery of CRISPR-Cas9. Mol Ther Nucleic Acids, 12:453-462, doi:10.1016/j.omtn.2018.05.010.

Lolli G, Raboni S, Pasqualetto E, Benoni R, Campanini B, Ronda L, Mozzarelli A, Bettati S, Battistutta R (2018) Insight into GFPmut2 pH Dependence by Single Crystal Microspectrophotometry and X-ray Crystallography. J Phys Chem B, doi:10.1021/acs.jpcb.8b07260.

Ferrara D, Pasetto L, Bonetto V, Basso M (2018) Role of Extracellular Vesicles in Amyotrophic Lateral Sclerosis. Front Neurosci, 12:574, doi:10.3389/fnins.2018.00574.

Coan M, Rampioni Vinciguerra GL, Cesaratto L, Gardenal E, Bianchet R, Dassi E, Vecchione A, Baldassarre G, Spizzo R, Nicoloso MS (2018) Exploring the Role of Fallopian Ciliated Cells in the Pathogenesis of High-Grade Serous Ovarian Cancer. Int J Mol Sci, 19(9), doi:10.3390/ijms19092512.

Vagner T, Spinelli C, Minciacchi VR, Balaj L, Zandian M, Conley A, Zijlstra A, Freeman MR, Demichelis F, De S, Posadas EM, Tanaka H, Di Vizio D (2018) Large extracellular vesicles carry most of the tumour DNA circulating in prostate cancer patient plasma. J Extracell Vesicles, 7(1):1505403, doi:10.1080/20013078.2018.1505403.

Bosco B, Defant A, Messina A, Incitti T, Sighel D, Bozza A, Ciribilli Y, Inga A, Casarosa S, Mancini I (2018) Synthesis of 2,6-Diamino-Substituted Purine Derivatives and Evaluation of Cell Cycle Arrest in Breast and Colorectal Cancer Cells. Molecules, 23(8), doi:10.3390/molecules23081996.

Lauria F, Tebaldi T, Bernabò P, Groen EJN, Gillingwater TH, Viero G (2018) riboWaltz: Optimization of ribosome P-site positioning in ribosome profiling data. PLoS Comput. Biol., 14(8):e1006169, doi:10.1371/journal.pcbi.1006169.

Piragyte I, Clapes T, Polyzou A, Klein Geltink RI, Lefkopoulos S, Yin N, Cauchy P, Curtis JD, Klaeylé L, Langa X, Beckmann CCA, Wlodarski MW, Müller P, Van Essen D, Rambold A, Kapp FG, Mione M, Buescher JM, Pearce EL, Polyzos A, Trompouki E (2018) A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways. Nat Commun, 9(1):3090, doi:10.1038/s41467-018-05311-4.

Szczurkowska J, Pischedda F, Pinto B, Managò F, Haas CA, Summa M, Bertorelli R, Papaleo F, Schäfer MK, Piccoli G, Cancedda L (2018) NEGR1 and FGFR2 cooperatively regulate cortical development and core behaviours related to autism disorders in mice. Brain, 141(9):2772-2794, doi:10.1093/brain/awy190.

Malchiodi L, Moro T, Cattina DP, Cucchi A, Ghensi P, Nocini PF (2018) Implant rehabilitation of the edentulous jaws: Does tilting of posterior implants at an angle greater than 45° affect bone resorption and implant success?: A retrospective study. Clin Implant Dent Relat Res, 20(5):867-874, doi:10.1111/cid.12655.

Tebaldi T, Zuccotti P, Peroni D, Köhn M, Gasperini L, Potrich V, Bonazza V, Dudnakova T, Rossi A, Sanguinetti G, Conti L, Macchi P, D'Agostino V, Viero G, Tollervey D, Hüttelmaier S, Quattrone A (2018) HuD Is a Neural Translation Enhancer Acting on mTORC1-Responsive Genes and Counteracted by the Y3 Small Non-coding RNA. Mol. Cell, 71(2):256-270.e10, doi:10.1016/j.molcel.2018.06.032.

Alessandrini F, Pezzè L, Menendez D, Resnick MA, Ciribilli Y (2018) ETV7-Mediated DNAJC15 Repression Leads to Doxorubicin Resistance in Breast Cancer Cells. Neoplasia, 20(8):857-870, doi:10.1016/j.neo.2018.06.008.

Iacovella MG, Bremang M, Basha O, Giacò L, Carotenuto W, Golfieri C, Szakal B, Dal Maschio M, Infantino V, Beznoussenko GV, Joseph CR, Visintin C, Mironov AA, Visintin R, Branzei D, Ferreira-Cerca S, Yeger-Lotem E, De Wulf P (2018) Integrating Rio1 activities discloses its nutrient-activated network in Saccharomyces cerevisiae. Nucleic Acids Res., 46(15):7586-7611, doi:10.1093/nar/gky618.

Yassour M, Jason E, Hogstrom LJ, Arthur TD, Tripathi S, Siljander H, Selvenius J, Oikarinen S, Hyöty H, Virtanen SM, Ilonen J, Ferretti P, Pasolli E, Tett A, Asnicar F, Segata N, Vlamakis H, Lander ES, Huttenhower C, Knip M, Xavier RJ (2018) Strain-Level Analysis of Mother-to-Child Bacterial Transmission during the First Few Months of Life. Cell Host Microbe, 24(1):146-154.e4, doi:10.1016/j.chom.2018.06.007.

Ferretti P, Pasolli E, Tett A, Asnicar F, Gorfer V, Fedi S, Armanini F, Truong DT, Manara S, Zolfo M, Beghini F, Bertorelli R, De Sanctis V, Bariletti I, Canto R, Clementi R, Cologna M, Crifò T, Cusumano G, Gottardi S, Innamorati C, Masè C, Postai D, Savoi D, Duranti S, Lugli GA, Mancabelli L, Turroni F, Ferrario C, Milani C, Mangifesta M, Anzalone R, Viappiani A, Yassour M, Vlamakis H, Xavier R, Collado CM, Koren O, Tateo S, Soffiati M, Pedrotti A, Ventura M, Huttenhower C, Bork P, Segata N (2018) Mother-to-Infant Microbial Transmission from Different Body Sites Shapes the Developing Infant Gut Microbiome. Cell Host Microbe, 24(1):133-145.e5, doi:10.1016/j.chom.2018.06.005.

Dassi E, Ferretti P, Covello G, HTM-CMB-2015, Bertorelli R, Denti MA, De Sanctis V, Tett A, Segata N (2018) The short-term impact of probiotic consumption on the oral cavity microbiome. Sci Rep, 8(1):10476, doi:10.1038/s41598-018-28491-x.

Boschian C, Messina A, Bozza A, Castellini ME, Provenzano G, Bozzi Y, Casarosa S (2018) Impaired Neuronal Differentiation of Neural Stem Cells Lacking the Engrailed-2 Gene. Neuroscience, 386:137-149, doi:10.1016/j.neuroscience.2018.06.032.

Carboni L, Marchetti L, Lauria M, Gass P, Vollmayr B, Redfern A, Jones L, Razzoli M, Malki K, Begni V, Riva MA, Domenici E, Caberlotto L, Mathé AA (2018) Cross-species evidence from human and rat brain transcriptome for growth factor signaling pathway dysregulation in major depression. Neuropsychopharmacology, 43(10):2134-2145, doi:10.1038/s41386-018-0117-6.

Dalle Vedove A, Spiliotopoulos D, D'Agostino VG, Marchand JR, Unzue A, Nevado C, Lolli G, Caflisch A (2018) Structural Analysis of Small-Molecule Binding to the BAZ2A and BAZ2B Bromodomains. ChemMedChem, 13(14):1479-1487, doi:10.1002/cmdc.201800234.

Caricasulo R, Malchiodi L, Ghensi P, Fantozzi G, Cucchi A (2018) The influence of implant-abutment connection to peri-implant bone loss: A systematic review and meta-analysis. Clin Implant Dent Relat Res, 20(4):653-664, doi:10.1111/cid.12620.

Ontañon OM, Landi C, Carleo A, Gagliardi A, Bianchi L, González PS, Agostini E, Bini L (2018) What makes A. guillouiae SFC 500-1A able to co-metabolize phenol and Cr(VI)? A proteomic approach. J. Hazard. Mater., 354:215-224, doi:10.1016/j.jhazmat.2018.04.068.

Cristofaro I, Spinello Z, Matera C, Fiore M, Conti L, De Amici M, Dallanoce C, Tata AM (2018) Activation of M2 muscarinic acetylcholine receptors by a hybrid agonist enhances cytotoxic effects in GB7 glioblastoma cancer stem cells. Neurochem. Int., 118:52-60, doi:10.1016/j.neuint.2018.04.010.

Sidarovich V, De Mariano M, Aveic S, Pancher M, Adami V, Gatto P, Pizzini S, Pasini L, Croce M, Parodi F, Cimmino F, Avitabile M, Emionite L, Cilli M, Ferrini S, Pagano A, Capasso M, Quattrone A, Tonini GP, Longo L (2018) A High-Content Screening of Anticancer Compounds Suggests the Multiple Tyrosine Kinase Inhibitor Ponatinib for Repurposing in Neuroblastoma Therapy. Mol. Cancer Ther., 17(7):1405-1415, doi:10.1158/1535-7163.MCT-17-0841.

Fagnocchi L, Poli V, Zippo A (2018) Enhancer reprogramming in tumor progression: a new route towards cancer cell plasticity. Cell. Mol. Life Sci., 75(14):2537-2555, doi:10.1007/s00018-018-2820-1.

Zasso J, Ahmed M, Cutarelli A, Conti L (2018) Inducible Alpha-Synuclein Expression Affects Human Neural Stem Cells' Behavior. Stem Cells Dev., 27(14):985-994, doi:10.1089/scd.2018.0011.

Pinazza M, Ghisi M, Minuzzo S, Agnusdei V, Fossati G, Ciminale V, Pezzè L, Ciribilli Y, Pilotto G, Venturoli C, Amadori A, Indraccolo S (2018) Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells. Oncogene, 37(28):3839-3851, doi:10.1038/s41388-018-0234-z.

Negro S, Stazi M, Marchioretto M, Tebaldi T, Rodella U, Duregotti E, Gerke V, Quattrone A, Montecucco C, Rigoni M, Viero G (2018) Hydrogen peroxide is a neuronal alarmin that triggers specific RNAs, local translation of Annexin A2, and cytoskeletal remodeling in Schwann cells. RNA, 24(7):915-925, doi:10.1261/rna.064816.117.

Perez-Romero CA, Lalonde M, Chartrand P, Cusanelli E (2018) Induction and relocalization of telomeric repeat-containing RNAs during diauxic shift in budding yeast. Curr. Genet., 64(5):1117-1127, doi:10.1007/s00294-018-0829-5.

Kundel F, Tosatto L, Whiten DR, Wirthensohn DC, Horrocks MH, Klenerman D (2018) Shedding light on aberrant interactions - a review of modern tools for studying protein aggregates. FEBS J., 285(19):3604-3630, doi:10.1111/febs.14409.

Manzano R, Sorarú G, Grunseich C, Fratta P, Zuccaro E, Pennuto M, Rinaldi C (2018) Beyond motor neurons: expanding the clinical spectrum in Kennedy's disease. J. Neurol. Neurosurg. Psychiatry, 89(8):808-812, doi:10.1136/jnnp-2017-316961.